Abstract:

Objective: Intra-articular platelet-rich plasma PRP (platelet-rich plasma) treatment can be applied at an early stage of Gonarthrosis in addition to medical treatment. There is no consensus in the literature regarding the dose interval of PRP. Our aim in this study is to compare the short-term clinical results of three doses of PRP administered at one and two-week intervals in the treatment of early-stage Gonarthrosis. Material and Methods: Three doses of PRP were applied to one knee of the patients at intervals of one week and to the other knee at intervals of two weeks. All patients were clinically evaluated with McMaster Universities Arthritis Index (WOMAC) and Visual Analogue Scale (VAS) before the PRP application and at the 1st, 3rd and 6th months after the application. Results: The mean age of 61 (40 female, 21 male) patients included in this study was 56.75 years and the mean BMI (Body Mass Index) was determined as 25.45±3.15 kg/m2. In the clinical evaluation at the end of the 1st, 3rd, and 6th months after PRP, there was no significant difference between the one-week interval and two-week application. However, it was observed that PRP application provided statistically significant improvement in WOMAC and VAS scores in both applications (p<0.05). Conclusion: According to the findings we obtained in our study, it has been determined that there was no difference between applying three doses of PRP at one- or two-weeks intervals.

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