Abstract:

Objective: This study aims to investigate the role of oxidative stress in pathogenesis of Lipoid Proteinosis (LP) by measuring the parameters of serum oxidative stress such as total antioxidant status (TAS), total oxidant status (TOS), advanced oxidation protein products (AOPP), oxidative stress index (OSI), ferric reducing antioxidant power (FRAP), lipid hydroperoxide (LOOH) and total free sulfhydryl groups (Total-SH). Materials and Methods: Fourteen patients with LP diagnosed clinically, radiologically and histopathologically and 14 sex-, age- and body mass index- matched healthy volunteers were included in this prospective case-control study. Serum TAS, TOS, AOPP, FRAP, LOOH and Total-SH were measured spectrophotometrically and OSI were calculated. Results: Cases with LP had significantly lower serum levels of TAS, FRAP and Total –SH (p< 0.001, for each) and higher levels of OSI, AOPP and LOOH (p= 0.001, p= 0.018, and p= 0.047, respectively). Serum TOS levels were higher in the LP group when compared to that of the control group, but it was not statistically significant (p= 0.081). ROC analysis demonstrated that TAS, FRAP, Total-SH and OSI levels independently predicted LP with strong sensitivity and specificity. Conclusion: Our results demonstrate that decreased levels of antioxidant parameters and increased levels of oxidant parameters might be used as an ancillary laboratory tests in the diagnosis of LP disease.