Özet:

Background: Ventilator associated Pneumonia is a common hospital acquired infection that occurs more than 48 hrs of mechanical ventilation (MV). VAP shows high incidence and mortality in ICU’s and become threat to the patients undergoing treatment.Material & Method: A prospective study over three years included patients on Ventilator and clinically diagnosed as VAP. Quantitative cultures were made from the endotrachel aspirates, collected from the patients. The bacterial isolates were identified as per laboratory protocol. Antimicrobial detection tests were performed by the Kirby Bauer Disc Diffusion Method.Result: A total number of 300 Endo-tracheal (ET) secretion samples were collected from the patients with the suspected ventilator associated pneumonia and processed as per laboratory protocol. Single isolate was grown in 85% which represents the magnitude of VAP. It was observed that 112 (43.9 %) isolates were identified in early VAP patients and 143 (56.07%) isolates were identified from late VAP patients. The predominant gram negative isolate was Acinetobacter spp. 122 (41%) followed by Klebsiella spp 52 (20.39%), Pseudomonas spp. 47 (18.43%), Escherichia coli 32 (12.54%), Enterobacter aerogens 7 (2.74%) and Citrobacter spp. 5 (1.96%).  Among the gram negative bacilli, 36.8% were resistant to Imipenem,, 67.8% resistant to cefoperazone- sulbactam and 87.4% resistant to Ceftazidime. All gram negative isolates were sensitive to Colistin, Polymixin B and Tigecycline.Conclusion: A local antibiogram pattern for each hospital is required to start empirical therapy based on bacteriological profile and susceptibility. This study may help clinicians in prescribing appropriate antimicrobials.

Anahtar Kelimeler: