Abstract:

Acne vulgaris (AV) is a common dermatological problem in adolescence. Several etiological factors such as genetics, hormonal, ultraviolet radiation, microorganisms, cosmetics and stress are believed to be responsible for AV. In our study, we aimed to assess the oxidative/ antioxidative status in adolescents with AV. Nine five patients who were clinically diagnosed with AV were included in the study. Forty seven healthy controls of the same age, gender and socioeconomic status were included in the study. Acne severity was assessed by global acne grading system(GAGS). Serum total oxidant status (TOS) and total antioxidant status (TAS) and oxidative stress index (OSI) in patients and control subjects were measured by the Erel method. TAS, TOS and OSI levels of patients compared with control group. TOS and OSI levels of patients found statistically higher than controls (p=0.04 and p=0.05 respectively), but there was not statistically significant difference between TAS levels (p>0.05). Severity of the disease and oxidative status levels did not show a statistical correlation (p>0.05). Oxidative mechanisms may play an important role in etiogenesis and progression of the AV. Besides conventional acne drugs, novel drugs modulating oxidative balance may be useful in treatment

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