Selective serotonin reuptake inhibitors (SSRI) are frequently used in the treatment of many psychiatric disorders such as major depressive disorder, anxiety disorder, and eating disorders. Side effects such as increased appetite, constipation, dry mouth, sedation, restlessness, sweating and sexual dysfunction due to SSRI use are frequently reported, while extrapyramidal syndromes (EPS) such as akathisia, dystonia and parkinsonism are rarely seen. There are reports of SSRIs such as fluoxetine, sertraline and fluvoxamine-induced EPS. We hereby report a 37-year-old male case of EPS such as oromandibular dystonia, akathisia, parkinsonism that developed after a chronic use of paroxetine 30 mg/day and its improvement with dose reduction. In this patient, paroxetine was discontinued as dose-reduced paroxetine was not sufficient to treat anxiety symptoms, and the use of escitalopram significantly reduced psychiatric symptoms.
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