Abstract:

Goal: Gastrointestinal stromal tumors (GSTs) are the most common mesenchimal tumors of the gastrointestinal tract. It is believed that they are derived from the interstitial Cajal cells that regulate the peristalysis of the gastrointestinal system. Gastrointestinal stromal tumors are a heterogeneous group of tumors with different morphological and biological behavior characteristics, so they can show different epidemic, clinic pathological and prognostic characteristics in different countries. The aim of this study is to analyze the histopathological, immune-histochemical characteristics and risk groups of 100 phenomena diagnosed with GIS in the last 10 years. Patients and Method: Between 2006 and 2016, 100 of the phenomena diagnosed with GIS in our pathological laboratory were retrospective. Risk groups were determined according to the diameter and mitoz rates of the incidents. The relationship between the histopathological and immune-histochemical characteristics and the risk groups, except the diameter and mythos, was analyzed. In the analysis of the data, Chi-quare-Fischer tests were used. In our cases, age and gender distribution does not vary according to risk groups. The most; respectively, the colorectal, extra gastrointestinal system (mezental, omental and retroperiton), thin abdomen and stomach GIS are in the high risk group. Thin stomach, colorectal and extra gastrointestinal tumors are bigger diameter and stomach tumors are smaller diameter. The immune chemical CD-34, S-100, SMA, is not associated with the risk groups with the expression of desmin. Tumors with expression above 10 percent of Ki-67 are in the high risk group. The stomach and extra gastrointestinal tumors show more CD-34 expression. Necrosis and bleeding tumors and high cellularity tumors have increased the chances of being in a higher risk group. There is no relationship between multiplication, growth paternity and atypic and risk groups. The result: Gysts are from rare tumors of the gastrointestinal system and may occur in different areas, in different variations. The detailed study and classification of GITs in the histopathological and immune-histochemistry according to the risk groups plays an important role in clinical treatment and follow-up.