Abstract:

Objective : Object of this study is to determine the effect of cilostazol on arterial compliance, distensibilty and vascular stiffness in carotid, femoral and brachial arteries through non-invasive methods in patients with stable IC/PAD. Material and Methods: Twenty-nine patients (22 male, 7 female) who had been treated with cilostazol 100 mg twice daily during six month were included in the study. Ultrasound measurements of carotid, femoral and brachial arteries were performed at baseline, at 3 and 6 months afer starting of treatment and the evaluation of the arterial stiffness measurements were performed by the pre-defned method. Results : Te mean age of the participants was 64 years. Pulsatility index, resistive index, systolic/diastolic velocity ratio, intima-media thickness and elastic modulus values were decreased while cross-sectional compliance, cross-sectional distensibility and diastolic wall stress values were increased with treatment in carotid, femoral and brachial arteries. Carotid, femoral and brachial arteries have similar rates of change. Conclusion : Cilostazol treatment reduced the progression of atherosclerosis without increasing the risk of bleeding in patients with peripheral arterial disease during a long-term follow-up  

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