Özet:

In this study, we compared two different dose (0.15 mg/kg versus 0.2 mg/kg) of cisatracurium besilate which is a new nondepolarizing neuromuscular blocker. Forty patients, in ASA I-II status were studied, except has respiratory or cardiovascular disorder, allergy, pregnancy and intubation difficulty. None of them were premedicated. All patients were monitored with EKG, SpO2 noninvaziv arterial pressure and neuromusculart moniteur (TOF-Guard, Organon Tecnica). At the induction of anesthesia intubation was performed after 0.15 mg/kg (Group I) and 0.2 mg/kg (Group II) cisatracurium besilate was injected and waited for 2 minutes because of the single twitch depression reach 95 %. Intubation conditions were scored with Goldberg’s scale. Heart rate, systolic, diastolic and mean arterial pressure were enrolled; before, 5 minutes and 10 minutes after intubation. Adverse effects (bradycardia, hypotension, airway spasm, rush and flush) which was occured after 10 minutes from the induction of anesthesia, also were enrolled. Haemodynamic values were evaluated with student’s t test, and for intubation conditions and adverse effects, Wilcoxon test was applied. Intubation conditions were perfect or good in both groups without ana significant differences (p>0.05). There was no significant difference in demographic data (age and weight), heart rate, systolic, diastolic and mean arterial pressure between two goups either (p>0.05). But Group II had more advers effects (bradycardia and hypotension) than Group I and this was a significant difference between higher dose group and lower dose one (p<0.05). In summary higher dose (0.2 mg/kg) cisatracurium besilate has more advers effects against lower (0.15 mg/kg) dose, without any significant changes about haemodynamic values or intubation conditions.

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