Abstract:

Introduction: cancer is still a health problem worldwide. Cervical cancer is the second most common cancer in women in developing countries. High-risk Human Papillomavirus (HPV) is well recognized as the causative agent of cervical cancer. Squamous cell carcinoma and adenocarcinoma are the most and the second most common histopathological type. HPV genotypes probably correlate to histopathological type. This study aims to prove that infection by HPV-18 gives a greater risk for the occurrence of cervical adenocarcinoma compared with infection by other high-risk HPV types. Methods: This study was case control study that used adenocarcinoma with HPV-18 positive patients as the case group and adenocarcinoma with positive with other high-risk HPV types as the control group. Histopathological diagnosis performed on H & E stain. Genotyping of HPV used SPF-10 and specific E7-primer by LiPA. Bivariate analysis was employed to calculate odds ratios (ORs) and Pearson’s X2 test was applied. Result: Total number of adenocarcinoma observed in this study were 42 patients, consisted of 12 cases and 30 controls. The most prevalence adenocarcinoma occurred in the age group 41-50 years. The risk of adenocarcinoma in patients with HPV-18 infection was 2.88 fold compared with infection by other high-risk HPV types (95% CI = 1.12-7.38; p = 0.024). Conclusion: HPV-18 infection caused cervical adenocarcinoma is 3.0 more than other high-risk HPV types

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