Özet:

Bacground: Our study was planned to reveal the objective relation between urine cotinine level and tobacco smoke exposure in children suffering from chronic cough. Methods: Between ages 5-18 years, 58 patients with chronic cough with no underlying specific cause and 54 healthy individuals were included in the study. Results: There was a statistically significant difference between urine cotinine levels of cases those who exposed and unexposed (based on the declaration of parents) to tobacco smoke (p<0, 05). The highest mean value of cotinine (41.3±73.7) was detected in the cases of chronic cough group who exposed to smoke. The best “cut-off value” for discriminating exposed and unexposed group was found to be 12.15 ng/ml with ROC analysis. Smoking ratio during pregnancy has been found higher in the group with chronic cough (p<0, 05).FEV1/FVC ratio was found to be lower in patients with chronic cough who are passive smokers when compared with the cases in the other groups (p<0,05). Conclusions: This is the first study objectively evaluating chronic cough effect of passive smoking with urine cotinine level. Since there is a meaningful decrease in FEV1/FVC ratio, close follow up is needed especially in children diagnosed as chronic cough who are exposed to tobacco smoke.

Anahtar Kelimeler: