Özet:

Aim: The aim of this study is to investigate the effect of single-dose intravitreal Dexamethasone (DEX) implant on peripapillary retinal nerve fiber layer (RNFL) thickness and cup-to-disc (C/D) ratio in patients with diabetic macular edema. Material and Methods: Peripapillary RNFL thickness measurements and colored fundus photographs were compared before and 6 months after intravitreal DEX implant injection. The cup-to-disc ratios of fundus photographs were calculated using the Image-J program. Results: Fifty-eight eyes of 43 patients were treated with intravitreal DEX implants. The mean global and sectoral peripapillary RNFL thickness value had a slight thinning over the basal value. The global and nasal thinning was statistically significant (respectively p=0.021, p=0.036). A small increase in C/D value was observed 6 months after the DEX implant injection however, these changes were not statistically significant (p=0.285). The intraocular pressure was over 25 mmHg in 17% of the patients and it was controlled by medical treatment. Conclusion: In this study, in patients with diabetic macular edema, a mild but significant thinning of the global and nasal peripapillary retinal nerve fiber layer was observed 6 months after single-dose intravitreal implant treatment. This reduction did not cause a significant morphological change in the C/D value.

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