Özet:

Anti-hyperglycemic agents is a substance that helps a person with diabetes controls their level of glucose (sugar) in the blood. It includes insulin and the oral anti hyperglycemic agents. Diabetes is a metabolic disorder that is characterized by increased levels of blood glucose leading to other major complications. Thus there prevails a necessity for obtaining these anti hyperglycemic agents through easily available flora. Delonix regia, is a tree cultivated across the world, has also been used as traditional medicine in various disorders. Aim of the project work was to evaluate the anti hyperglycemic activity in the hydroalcoholic extract of Delonix regia bark for the treatment of hyperglycemia. The collected bark was dried, powdered and extracted through cold maceration method. The extract was further concentrated to obtain a gummy mass of the hydroalcoholic extract. The extract was subjected to phytochemical analysis through conventional chemical tests and GC-MS. After the identification of the phytoconstituents, they were studied for their clinically proven properties. In vitro anti hyperglycemic studies were carried out through assays like alpha-amylase inhibition assay and alpha-glucosidase inhibition assay. The results of the extract were compared with results of standard acarbose. The IC50 values of standard in alpha-amylase inhibition assay and α-glucosidase inhibition assay was 98.77µg/ml and 84.33µg/ml respectively. The IC50 values of hydroalcoholic extract of Delonix regia bark in alpha-amylase inhibition assay and alpha-glucosidase inhibition assay was 167µg/ml and 116.31µg/ml respectively. From the study, hydroalcoholic extract of bark of Delonix regia exhibit antihyperglycemic activity compared to standard acarbose.

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