Özet:

Nanoemulsion is liquid in liquid dispersion with droplet size of about 100 nm, it has transparent appearance, high rate of bioavailability and increased shelf life. It is made up mainly of oil, water, surfactant and cosurfactant and can be prepared by high and low energy methods. Diluted nanoemulsion is utilized for the delivery of ophthalmic drugs due to their ability to penetrate the deeper layers of the ocular structure, provide sustained release effect, and reduce frequency of administration and side effects. These nanoemulsions are subjected to certain tests such as safety, stability, pH profile, rheological studies and soon. Cationic nanoemulsions are prepared for topical ophthalmic delivery of the active ingredients utilizing from cationic agents for increasing the drug residence time on the ocular surface, reducing their clearance from ocular surface and improving bioavailability of the drug. This article review summarizes the main characteristics of nanoemulsions, ophthalmic nanoemulsions, cationic nanoemulsions as well as their components, methods of preparation and evaluation parameters of ophthalmic nanoemulsions.

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