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Stability Indicating Simultaneous Validation of Aspirin, Clopidogrel and Rosuvastatin with Forced Degradation Behavior Study by RP-HPLC in Pharmaceutical Dosage Form
2017
Journal:  
Asian Pacific Journal of Health Sciences
Author:  
Abstract:

ltaneous validating anassay of Aspirin, Clopidogrel and Rosuvastatin in Capsule Dosage Form, a simple, precise and accurate RP-HPLC method has been developed. Isocratic RP-HPLC process was established on BDS hypersil C18 (250mm×4.6mm internal diameter, 5µ particle size) using mobile phase as 0.05M Potassium DihydrogenOrtho Phosphate (pH-4.0): Acetonitrile (60:40v/v) at a flow rate of 1.0 mL/min and at 235 nm the detection was carried out by using tunable absorbance detector (Waters 486). Forced degradation study was performed by acid, base and thermal degradation, as well as oxidation of the drug. The process was validated for accuracy, precision, linearity, and robustness. The method was found to be linear in the 15-45

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Asian Pacific Journal of Health Sciences

Field :   Sağlık Bilimleri

Journal Type :   Uluslararası

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Article : 1.419
Cite : 363
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Asian Pacific Journal of Health Sciences