Özet:

Introduction: This study aims to evaluate whether serum ferritin levels differ between recently diagnosed patients with type 2 diabetes mellitus (DM) and healthy controls, and to assess the relationship between serum ferritin level, insulin resistance and metabolic control in patients with type 2 DM. Material and methods: This study included 40 patients with recently diagnosed type 2 DM and 40 healthy controls. The Homeostasis Model Assessment of insulin resistance (HOMA-IR) score was used for evaluation of insulin resistance. HOMA-IR scores ≥2.7 were accepted as insulin resistance. The patient and control groups were compared in terms of age, gender, BMI, serum ferritin, insulin, HbA1c, and HOMA-IR scores. If ferritin levels correlated with other parameters was assessed in the patient group. Furthermore, patients with good (HbA1c<7%) and poor glycemic control (HbA1c≥7%) were compared regarding serum ferritin level. Results: Ninety percent (n=36) of the patient group and 27.5% (n=11) of the controls had HOMA-IR scores ≥2.7. Serum ferritin levels were significantly higher in the patient group (153.57±150.01 vs 62.83±53.18; p=0.003). There were significant positive correlations between serum ferritin and fasting plasma glucose levels (r=0.419 p=0.007), HbA1c (r=0.410, p=0.009) and HOMA-IR score (r=0.320, p=0.044) in the patient group. Mean serum ferritin level of patients with poor metabolic control (201.20±170.67) was significantly higher than ones with good metabolic control (91.92±71.39) among patients with type 2 DM (p=0.047). Conclusion: Serum ferritin levels were found to be higher in patients with type 2 DM than controls and there was positive correlation between serum ferritin levels and insulin resistance.