Özet:

Purpose: The purpose of this study is to investigate the possible relationship of chronic smoking with the levels of serum vitamin D and some inflammatory indicators. Tools and Methods: Serum 25(OH)D vitamin (VD), C-reactive protein (CRP) and full blood count requested 76 women and 34 men with a total of 110 volunteer adult smoking history was questioned. The laboratory data was collected from the Hospital Information Management System. All smoking and non-smoking groups and their female and male subgroups were compared with age, body mass index (BMI), outdoor stay time, leukocytes and subgroups, thrombocytes, average thrombocyt volume (MPV), neutrophil lymphocytes rate (NLR), thrombocytes lymphocytes rate (PLR), CRP and VD levels. The correlations of these parameters with the VD levels, the comparison of demographic and laboratory data on the categorized VD levels and the gender-based distribution were studied. The statistical significance was assessed at the level p< 0.05 (two-tailed). The period of smoking for smokers was 16.4±12.7 (1-50) years. There was no significant difference between the age, BMI, time of outdoor stay, CRP and VD levels of the smokers (n=40) and the non-smokers (n=70). In the total group smoking, the number of leukocytes and neutrophils was significantly higher than the non-smoking group (both p=0,001). In women, the number of neutrophils, the percentage and the NLR in smokers (n=22) were significantly higher than those who did not drink (n=54); the percentage of lymphocytes was significantly low (respectively p=0,011; p=0,005; p=0.017; p=0,031). In men, the number of leukocytes, neutrophils and lymphocytes was significantly higher than in smokers (n=18) (n=16) respectively (p=0,013; p=0,031; p=0,022). In smoking women, the percent of neutrophils and NLRs were higher than in men (relevantly p=0,004; p=0,011); lymphocytes and percentages were low (relevantly p=0,030; p=0,028). The VD levels of non-smoking men were significantly higher compared to women who did not drink (p=0,003). The MPV value did not differ in any group. In all non-smoking groups (n=70) there was a weak but meaningful correlation between the VD levels and the time of stay in the open air (rs=0,249; p=0,038). In the entire group of smokers, a negative correlation (rs=0,322; p=0,043 and rs=-0,313; p=0,049) was found in the positive direction between the levels of VD and the percent of lymphocytes; and the negative correlation (rs=0,322; p=0,043 and rs=-0,313; p=0,049) was found in the positive direction. The group of smoking men found a significant negative correlation between VD levels and leukocytes (rs= -0,564; p=0,015). The female frequency under the VD level <20 ng/mL was significantly higher than the male (p=0,011). The time of stay in the open air was significantly short, while the time of stay in the open air was statistically significant, and the time of stay in the open air was statistically significant, and the time of stay in the open air was statistically significant, and the time of stay in the open air was statistically significant, and the time of stay in the open air was statistically significant, and the time of stay in the open air was statistically significant. The result: Chronic smoking does not cause a change in the serum VD and CRP levels, while the increase in the number of leukocytes and neutrophils in total drinks and the number of lymphocytes in male drinks. The immune-modulating chemicals and gases contained in tobacco smoke may have caused the inflammatory reaction and the resulting cell defense mechanism may have caused this increase. The fact that non-smoking men have significantly higher serum VD levels compared to non-smoking women can be associated with participation in work life and clothing style. The fact that non-smokers have a significant positive correlation between the duration of their stay in the open air and the levels of VD, not in smokers, suggests that smoking has a negative impact on the VD synthesis. 73 per cent of the cases. The fact that 6 has a VD level below 30 ng/mL has shown that VD supplementation from the outside of our region is necessary.