Özet:

This study was designed to investigate the changes in total oxidant (TOS)/antioxidant (TAS) and oxidative stress index (OSI) levels in liver and kidney tissues of mice pre-treatment of artemisinin against oxidative stress that may occur in mice administered pentylenetetrazole (PTZ). Swiss albino mice (Male) (n=42) were used in the study. The mice were divided into six groups and each group had seven animals (n=7): (1) Control (C) /saline Group, (2) PTZ (35 mg/kg) Group, (3) Valproate (VPA) (100 mg/kg) + PTZ Group, (4) Artemisinin (ART) (30 mg/kg) + PTZ Group, (5) ART (60 mg/kg) + PTZ Group, (6) ART (120 mg/kg) + PTZ Group. Mice received injections intraperitoneally (ip). After the treatments, the animals were observed for seizures for 30 minutes. On the last day (day 26) of the experiment, the PTZ loading dose (75 mg/kg) was administered to the mice and then the animals were sacrificed. TAS, TOS and OSI levels were measured in liver and kidney tissue. PTZ increased TOS and decreased TAS in liver and kidney tissue. ART significantly increased TAS and decreased TOS in liver tissue at increasing doses (p<0.05). ART was not very effective in kidney tissue. However, TAS levels in kidney tissue were significantly higher when VPA was compared with other groups (p<0.05). In this study, it can be assumed that PTZ-induced oxidative stress may be due to the activation of glutamate receptors in peripheral tissues. ART may have a protective effect against liver damage due to PTZ-induced oxidative stress and hypoxia. This effect may be due to the antioxidant capacity of ART.