Abstract:

Introduction: Given that extubation after coronary artery bypass surgery has always been controversial, the aim of this study was to use different doses of dexmedetomidine (0.3 and 0.7 mg/kg) to facilitate extubation of patients after coronary artery bypass surgery. Method and Materials: A total of 78 patients of ASA classes II and III, who were candidates for coronary artery bypass surgery, were studied during the period from 2016 to 2017. Patients were divided into three groups, including the control group, and the two groups receiving 0.3 and 0.7 mg per kg body weight doses of dexmedetomidine. All of the collected variables, which consisted of three parts including: demographic, recovery, and hemodynamic information, were completely measured and analyzed. Result: The results were indicative of a higher preinduction arterial blood pressure level in the control group than in the groups receiving doses of dexmedetomidine (P < 0.05). The use of dexmedetomidine in patients having undergone coronary artery bypass surgery did not show a significant effect on their heartbeat rates (P < 0.05). Only four hours after the admission of the patient to the ICU, the cardiac index rate showed a significant increase with the increased dose of dexmedetomidine compared with that in the control group (P < 0.05). The use of a 0.7 mg/kg dose of dexmedetomidine significantly decreased the time taken to remove the tracheal tube compared with that in the control treatment (P < 0.05). The time taken to discharge the patients from the ICU was significantly decreased in the groups receiving dexmedetomidine compared with that in the control group. Concelusion: The results of this study showed that in the fast-track recovery of patients with coronary artery bypass surgery, dexmedetomidine was an appropriate drug for maintaining anesthesia, and provided good hemodynamic stability.

Keywords: