Özet:

Objective: The circadian system acts at whole levels of a woman’s life as a cornerstone: from follicle generation to the arrangement of hormonal balance; and the process from embryo implantation to birth. Methods: We compared the promoter methylation status of the circadian genes, BMAL1 and CLOCK, between pre-menopausal and postmenopausal women to find an epigenetic explanation in women with menopause. In this perspective, 56 postmenopausal women and 48 premenopausal women were enrolled in this study. Results: Menopause and methylation status of the BMAL1 or CLOCK genes did not show any statistically significant correlations (p˃0.05). Moreover, the correlation of the methylation pattern of the BMAL1 and CLOCK genes with age could not be detected (p˃0.05). Conclusion: The methylation status of the BMAL1 and CLOCK genes in menopause was characterized for the first time in our study. Further studies should shed light on this subject.

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