Abstract:

Progesterone, which is necessary for the maintenance of pregnancy, is produced by corpus luteum until the 10th week of pregnancy and then by the placenta. The aim of this study is to explore the relationship between serum progesterone concentrations measured in the 6-8-12 weeks of pregnancy and the parameters that may show placental dysfunction in the third trimester. The method assessed the relationship between progesterone values measured in the 6-8 weeks of pregnancy and 12 weeks of pregnancy and symptoms of placental dysfunction such as hypertensive disorders during pregnancy, intrauterine developmental tension, premature birth and low birth weight. Furthermore, on the basis of a previous study, two groups were formed according to the levels of progesterone above and below 11 ng/mL during early pregnancy and the differences between these groups were studied in terms of gestational results. Results The concentrations of progesterone in the 6-8 weeks of pregnancy and 12 weeks of pregnancy did not differ significantly between subgroups with and not having pregnancy complications indicating placental dysfunction (p>0.05 for all parameters). Due to the 11 ng/mL progesterone marginal value in the 6-8 weeks of pregnancy, there was no significant difference between the two groups in terms of third trimester complications. In this study, we found that progesterone values measured in the early and late periods of the first trimester were not associated with placental dysfunction in the third trimester. Also, we have not validated the previously recommended marginal value to predict the gestational result. Therefore, the routine first trimester progesterone screening may not be suitable in directing pregnancy tracking.

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