Özet:

Purpose: In our study, the relationship between immune reactivity of D2-40 in colon adenocarcinomas and tumor grade, clinical stage and lymphatic nod metastasis was studied.Method: In this study, 60 facts of colon adenocarcinoma diagnosed in our clinic were studied between 2002-2009. The D2-40 antibodies to the cuts made from the proper paraffin blocks of these phenomena have been studied with immunohistochemical methods.The findings: Immunohistochemical examination results in 18 of 60 phenomena (%30) found D2-40 hypo-positive immune reactiveness. According to the statistical analysis, there was no meaningful relationship between the histological grade (p:0,78), the clinical stage (p:0,91) and the lymphatic nod metastasis (p:0,56) and the immune reactiveness of D2-40. There was no correlation between the D2-40 immune reaction and the prognostic parameters we studied. However, in literature, we believe that there is a small number of studies that investigate the immunoreactivity in tumor cells in colon adenocarcinomas and that there is a need for further studies on this subject.

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