Özet:

Objective: Metabolic effects of dienogest (DNG) may lead to unintended lipid levels, which may predispose to cardiovascular diseases. The main objective of this study was to reveal effects of DNG only treatment on lipid profile. Methods: Thirty three otherwise healthy women with diagnosed endometriosis were started on 2 mg dienogest/day oral treatment. Blood samples were taken before and after 6 months of therapy to measure triglycerides (TG) low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and total cholesterol levels. Exclusion criteria were withdrawal from DNG treatment, pregnancy, women with incomplete medical records or who were lost to follow-up, allergies for DNG, need for laparoscopy during the 6-month of medical treatment, having familial lipid disorders, and body mass index (BMI) >30 kg/m2. Results: There was no significant difference regarding total cholesterol, HDL, and LDL levels between the blood samples taken before and after DNG treatment. However, TG levels were significantly higher at 6th-month blood samples than the pre-DNG blood samples (94 vs. 75, p=0.03). The mean age was 31.4±4.8 years, gravidity was 1.8±1.3, parity was 1.6±1.1, and BMI was 24.6±1.8 (kg/m2). Conclusion: Our results suggest that DNG treatment increases TG levels. The metabolic effects of DNG should be clarified as being widely used among women as a progestin-only regimen. Alterations in lipid metabolism may affect the use of this drug in patients with metabolic syndrome or hyperlipidemia.

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