Özet:

Ankylosan spondylitis (AS) is a chronic inflammatory disease that is unknown, which can mainly affect other joints, including the spine. AS is a prototype of spondyloartropatics and affects 0.9% of the world’s population. Sulfasalazine is one of the disease-modifying antiromatic drugs used in the treatment of AS. The phenomena that sulfasalazine causes negative effects on the central nervous system, including serious psychiatric problems such as mania, depression and psychosis, have been rarely. In this article, a male patient is presented due to a major depressive disorder with psychotic characteristics. While the patient develops severe psychiatric symptoms, he was taking 1000 mg of sulfasalazine per day for AS. As the patient consulted with the Romatology department was suspected that sulfasalazine could be the cause of psychiatric symptoms, the treatment of sulfasalazine was interrupted. The complaints completely dropped one month after the beginning of psychiatric treatment.

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