Özet:

OBJECTİVE: In this research, protective effect of omega – 3 fatty acids on kidney tissue is biochemically investigated. MATERİAL AND METHOD: For his purpose, 16 adult Wistar – Albino rats are divided into two groups and investigated. Rats in Group I are used as control group and they are only intragastric gavaged with normal saline. However, rats in Group II are intragastric gavaged daily with a dose of 400 mg/kg fatty acid. All rats are killed by using decapitation method at the end of six weeks experiment period. Kidney tissues collected from experimental subjects are spectrophotometric investigated for malondialdehyde level and superoxide dismutase (SOD), glutathione peroxidase (GSH – Px) enzyme activities. RESULTS: It has been observed that SOD and GSH – Px activities in kidney are statistically increased in rats treated with omega – 3 fatty acid. Along with this, there had been statistical decrease in their MDA levels compared to the results coming from control group subjects. CONCLUSİON: It is concluded that omega – 3 fatty acids prevent the oxidative damage in rat kidney tissue. These fatty acids have positive antioxidant effect, thus protect kidney tissue.

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