Abstract:

The effects of the therapies of hyaluronic acid (HA) and methyl prednisolone acetate (MPA) applied intraarticularly in degenerative arthritis is an experimental 9all!~ma yaplldl. 40 male raM sag rear knee joints i9ine 0.2 ml of 1% lormalin was tested with experimental arthritis. A week after IIa9 was given, 10 rat 61dunJlerek arthritillin is histopathologically be/iried. The remaining 30 runs are equal to 3 groups. The first group was given 0.05 ml of intraarticular HA (HA group), and the second group was given 0.05 ml of intraarticular Liler MPA (MPA group). In the 09th group, intraarticulates were placed in the control group of 0.05 ml of serum lizyological veins. Treatment of arthritis is done after 7. The Gun, 14. Gun and the 21st gun. After the completion of these treatments on 15 July, the rat/ar 61duriilds and German shoulders were histopathologically examined. In the review made in the MPA group, clkmjak heal$see a9lsm to control group g6re! The difference is not found (p>0.05). In the HA group, it was found that it had a significant improvement in the MPA and control group (p<0.05). Intraarticals in the treatment of arthritis have resulted in the positive effects of the HA to MPA's g6re more useful. Keywords: Oneal arthritis, clclrdak, hyaluronic acid, methyl prednisolone acetate. This experimental study was performed to determine the effects of intraarticular hyaluronic acid (HA) and methyl prednisolone acetate (MPA) in degenerative osteoarthritis. 0 is. 2 ml 1% formalin were injected to the posterior right knee joints of 40 male rats. One week after the injections. 10 rats were killed and arthritis was determined histopathologically. The remaining 30 rats were divided into three groups. First group received intraarticularly 0.05 ml HA (HA group), second group 005 ml MPA (MPA group) and third group 0.05 ml saline as controls. The injections were performed at 7, 14 and 21 days after the arthritis. 15 days after the end of these treatments, rats were killed and sections were examined histopathologically. There was no significant difference in cartilage healing between MPA and control groups (p>0.05). However cartilage healing was significantly high in HA group compared to MPA and control groups (p<0.05). It was concluded that HA is more useful than MPA in the treatment of arthritis intraarticularfy because of its positive effects on cartilage tissue. Key words: Experimental arthritis, cartilage, hyaluronic acid, methyl prednisolone acetate.