Özet:

Objective: The aim of this study is to search the effects of hepatic iron deposition for the liver fibrosis and inflammation in patients with chronic hepatitis C (CHC).Materials and Methods: The records of 70 patients with CHC who had not previously been treated with antiviral therapy were reviewed retrospectively. The liver biopsies of these patients have been scored in terms of inflammation and fibrosis with the method of modified ISHAK by only one pathologist. Preparations were prepared from these liver biopsies were stained with Persl' Prussian blue. Hepatic iron deposition was evaulated using the method of semicantitative modified MacSween by the same pathology. Results: In the histopathological evaluation of liver biopsy samples, increased liver iron deposition has been found in 25 patients (38.5%). A significant relationship has been found between increased hepatic iron deposition and histological activity index (HAI) (p=0.001), but not found fibrosis degree (p>0.05). Fibrosis and HAI degrees were higher in patients with severe-moderate hepatic iron deposition.In conclusion: Increased hepatic iron deposition may be associated with severe hepatic fibrosis and inflammation in patients with chronic hepatitis C.

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