Özet:

Objective: To investigate the protective effects of iloprost and low-dose methotrexate on ischemia/reperfusion (I/R) injury in surgically detorsed testicular torsion. Material and Methods: Rats were randomly divided into 4 groups: Group 1 (sham), Group 2: Only testicular I/R; Group 3: I/R+iloprost (10 μg/kg) and Group 4: I/R+low dose metotrexate (6 mg/kg). Torsion / ischemia and detorsion / reperfusion times were determined as 4 hours. Medications were given intraperitoneally at 3 hours following onset of testicular torsion. Detorsioned right testises were removed 8 hours after the begining of the procedure in all 4 groups. Results: In our study, we found that administration of iloprost and metotrexate significantly increased total antioxidant capacity (TAC) while reducing total oxidant statüs (TOS) and oxidative stress index (OSI) levels significantly. No statistically significant difference was found for testicles in I/R groups according to the Johnsen scoring system. Conclusion: Admnistration of iloprost and low dose methotrexate treatment increased antioxidant activity in testicular samples while suppressing oxidant activity. However, there was no change in histopathological examination and spermatogenesis scores.

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