Özet:

The aim of the work. To substantiate the composition and technology of perspective cosmetics with silver, gold and copper nanoparticles. Materials and Methods. Colloidal solutions of silver, gold and copper nanoparticles synthesized in the F.D. Ovcharenko Institute of Biocolloidal Chemistry of the National Academy of Sciences of Ukraine were used to develop cosmetic products. Antimicrobial activity of colloidal solutions of metals nanoparticles in vitro was determined by serial dilutions in agar. The safety of colloidal solutions of silver, gold and copper nanoparticles was determined in in vitro tests by indexes of cytotoxicity, genotoxicity, mutagenicity, immunotoxicity and biochemical markers. Methods of information retrieval, analysis of literature data and technological research were used to substantiate the composition and technology of cosmetic products. Results and Discussion. Results of the metal nanoparticles’ antimicrobial activity estimation showed that silver and copper nanoparticles exhibit pronounced bactericidal action, gold nanoparticles have a weak antimicrobial activity. As to the level of safety of investigated nanoparticles, the studies indicate the safety and expediency of their subsequent medical and biological use. Taking into account the peculiarities of the requirements for the introduction of cosmetic products into the market in comparison with medicinal preparations, in particular the absence of mandatory requirements for qualitative and quantitative analysis of nanoparticles in a cosmetic product, only the need of sanitary hygienic examination, the prospects of metals nanoparticles as biologically active components of cosmetics determined. The composition and technology of the gel for oily skin care, in which as active components a solution of copper nanoparticles and Amaranth oil were used, cream for the aging skin care with gold nanoparticles and lip balm with anti-herpes action based on silver and gold nanoparticles were substantiated. Conclusions. The obtained results show the prospect of further study of cosmetics based of metals nanoparticles, what will promote the expansion of the nomenclature of innovative cosmetic products.

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