Abstract:

Background: Gensini score, an angiographic scoring system, is used to evaluate the extent and severity of coronary artery disease. High Gensini score and von Willebrand factor level are associated with poor cardiac events in patients with acute coronary syndrome. In this study, we aimed to investigate the relationship between Gensini score and von Willebrand factor level in patients with acute coronary syndrome Materials and Methods: The study included 141 patients with acute coronary syndrome who underwent coronary angiography. Patients with gensini score <32 were defined as group 1, while patients with gensini score ≥32 were defined as group 2. Angiographic characteristics and plasma von Willebrand factor level were compared between two groups. Results: When compared to group 1 patients, group 2 patients had significantly higher levels of von Willebrand factor (140 IU [101-149] vs. 120 IU [100-134], P = 0.010). In correlation analysis, Gensini score and von Willebrand factor level was positively correlated (r = 0.228, p = 0.007). Multivariate logistic regression analysis demonstrated that Willebrand factor was an independent predictor of high gensini score (odds ratio, 1.013; 95% confidence interval, 1.002 - 1.026, P <0.027]. von Willebrand factor level ≥ 128 IU predicted high gensini score with a sensitivity of 59% and specificity of 63%. Conclusion: High von Willebrand factor level is independently associated with high gensini score in patients with acute coronary syndrome.