Abstract:

The aim of our study is to identify the relationship between the level of serum iris in patients with metabolic syndrome (MetS) and insulin resistance indicators and cardiovascular disease (KVH) risk factors. Method and Requirements: According to the International Diabetes Federation (IDF), 46 patients with MetS and 26 patients in the control group were included. Serum iris levels, KVH risk factors (gender, age, obesity, lipid disorders, smoking, hypertension (HT), family history) and insulin resistance indicators (HOMA-IR, Triglyceride (Trg)/High-intensity lipoprotein (HDL), back circle (BC) and body mass index (VKI) were studied. 28 of the patients involved in the study were male (42%) and 38 (58%) female. The average age was 43.78 ± 14.16. 25 (38%) patients had HT, 19 (29) obesity, 31 (47) smoking, and 32 (48) families had KVH history. The average level of serum iris in all study patients was 7.27 ± 4.65. Serum irisine levels were significantly lower in patients with metabolic syndrome compared to the control group (5.47 ± 2.51 vs. 10.06 ± 5.47, p <0.001). Negative correlation between age and serum iris levels was identified. There is no statistically meaningful relationship between the levels of serum iris and gender, smoking, family KVH history, HDL, LDL, Trg, total cholesterol levels (p,0.502; p,0.974; p,0.264; p,0.783; p,0.648; p,0.286; p,0.128, respectively). Serum irisine levels, except HbA1c, are not correlated with insulin resistance indicators (HOMA-IR, Trg / HDL, WC/HC, and BMI). A negative correlation between the serum irisine level and HbA1c was found (B=-0.935, p=0.03). CONTRACT and RESULT: Serum iris levels were significantly lower in MetS patients. Except for HbA1c and age, there is no meaningful relationship between KVH risk factors and insulin resistance indicators.

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