Özet:

Objective To investigate the effects of systemic isotretinoin therapy on retinal nerve fiber layer (RNFL) thickness and corneal endothelial cell density (ECD) Methods Thirty-three patients completed the study. All patients were given an ophthalmic examination at baseline and after six months of isotretinoin therapy. All patients underwent a detailed eye examination including best corrected visual acuity, intraocular pressure, refractive errors, biomicroscopic anterior segment and fundus examination. In addition, Schirmer test without topical anesthesia, tear break up time, retinal nerve fiber thickness measurements with optical coherence tomography (OCT) and specular microscopy measurements were performed on all patients. Results There were 23 female (69.7 %) and 10 male (30.3 %) patients. Post treatment RNFL values were significantly lower than pretreatment values on both right and left eyes (P=0.048 and P<0.001). We did not find any correlation between total dose of isotretinoin and mean RNFL thickness values on both right and left eyes (P=0.118, P=0.909). There were no significant differences in the mean Schirmer scores, Break up time values of both eyes during the treatment compared with the baseline values. There were significant differences in corneal ECD between pre and postreatment period (P=0.017, P=0.006). Conclusion After the use of oral isotretinoin for six months, we found decreased RNFL and CCT thickness by OCT.

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