Özet:

The developments in the field of biotechnology have put genetic therapy in the forefront of medical research and have led to the use of today’s genetic principles to improve oral and dental health. The meeting of these new technologies with dental medicine has been provided by the scientific stages recorded in the production of restorative biometry, tissue engineering, the use of molecular biology and the human genom project. Gen therapy is the replacement or repair of a defective gene with a therapeutic gene using a special method. It can be used in the treatment of many diseases and in the correction of genetic disorders. Dentofasal applications in gene therapy in dental medicine include bone regeneration, DNA-based immunization (small and periodontal diseases), pain treatment, autoimmune diseases treatment and cancer treatment. In general, research is aimed at developing new vector systems and transportation methods, testing them, clarification of mechanisms that include vector transduction, and the use of approaches that can give good results in clinical trials. Over the past 15 years, a variety of vectors for genes and drug carriers have been developed. Gen therapy has a significant scientific basis in the field of dentistry. This collection aims to update the gene therapy methods, the relevant vectors, the clinical effect of gene therapy in dentistry and the scientific information on the subject. Keywords: gene therapy, gene therapy, gene therapy, genetic vectors GENE THERAPY IN DENTISTRY (REVIEW) ABSTRACT Advances in biotechnology have brought gene therapy to a very important and active area of medical research and currently genetic principles are being applied along to improve oral health. Scientific advances in restorative biomaterials, tissue engineering, molecular biology and the human genome project provide the basis for the introduction of new technologies into dentistry. Gene therapy is a particular method by which missing or defective genes are replaced or repaired by normal genes. It can be used to treat a wide range of diseases and correct genetic disorders. In dentistry the application of gene therapy to dentofacial problems includes bone regeneration, DNA-based immunization (for caries and periodontal disease), pain, for treating autoimmune disease and cancer. The general approach is to develop new vector systems and delivery methods, test them, uncover the mechanisms involved in vector transduction, and use the most promising approaches in clinical trials. For the past 15 years various vectors have been designed for improved gene and drug delivery. This field is having significant impact on topics related to dental practice. The aim of this review is to provide an update on gene therapy methods, its clinical implication in dentistry and scientific information associated with gene therapy. Keywords: gene therapy, gene therapy, genetic vectors

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