Abstract:

Background: Hypertension is an important risk factor for cardiovascular diseases. Studies with ambulatory blood pressure monitoring (ABPM) have revealed that blood pressure changes during the day and has a circadian rhythm. Decreasing 10% or above in blood pressure during the night is called dipper; if not so is called non-dipper hypertension(HT). Cardiovascular risk increases in patients with non-dipper hypertension. Copeptin ise antidiüretik hormonun parçası olan bir molüküldür. In some studies, copeptin level in the blood shows a rapid increase in conditions such as cardiovascular diseases, cerebrovascular diseases, sepsis and shock. In this study, we aimed to compare serum copeptin levels in dipper and non-dipper patient groups. Materials and Methods: 73 patients newly diagnosed with HT were included in this study as the study group and 35 healthy individuals as the control group. Individuals diagnosed with HT were divided into dipper HT and non-dipper HT subgroups according to ABPM. The basic biochemical parameters and copeptin levels of all individuals included in the study were studied. Results: Serum copeptin levels of individuals with non-dipper HT were found to be significantly higher than serum copeptin levels in both control and dipper patient groups. A positive correlation was observed between copeptin and triglyceride in double correlation analysis. No statistically significant correlation was found between other biochemical markers and copeptin. Conclusion: Serum copeptin levels were found to be high in the non-dipper hypertensive patient group with a poor prognostic course. This finding suggests that increased copeptin level is associated with the prognosis of patients with non-dipper HT. Therefore, copeptin level can be used as a prognostic parameter in patients with hypertension.