Abstract:

OBJECTIVE: Hashimoto's thyroiditis (HT) is an autoimmune disease which becomes evident by impaired immune tolerance because of immunologic, genetic and environmental factors. HT is the most frequent form of autoimmune thyroid diseases. It occurs more frequently in women with prevalence ratios ranging from 5 to 10:1. Relationship between HT and thyroid tumors is still controversial. It's said that there is a higher risk in HT for growing papillary thyroid carcinoma. In addition, the non-papillary thyroid carcinomas that are analyzed with HT are defined in literature. In this study coexistence of HT and thyroid tumor and also tumor subtypes are analyzed. Furthermore relationship between this coexistence and clinicopathologic parameters are discussed with reference to the literature. MATERIAL and METHODS: In this study, the slides of 382 cases that were diagnosed as HT in the thyroidectomy specimens between 1990-2011 are analyzed by light microscopy. Age, sex, preoperative diagnosis and operation types are investigated in addition to the malignancy. RESULTS: In this study 382 cases of HT were analyzed retrospectively. In 13,6% of cases (52 cases) thyroid neoplasm was detected. Of these tumors 71,1% (37 cases) were papillary carcinoma, 13,5 % (7 cases) were follicular carcinoma and 15,4% (8 cases) were follicular adenoma. In 70,2% of cases tumor diameter is under 1 cm in all papillary carcinomas. CONCLUSION: In this study, relatively frequent coexistence of thyroid neoplasm and HT besides collocation of frequent small tumor diameter is determined. Coexistence of HT and thyroid neoplasm has been found consistent with literature.

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