Abstract:

Abstract Gated myocardial perfusion SPECT (g-MPS) is an important method in the diagnosis of coronary artery disease (CAD). Left ventricular ejection fraction (LVEF), end-systolic volume (ESV) and end-diastolic volume (EDV) are required parameters for evaluation of cardiac performance. Our aim is to compare LVEF and volume values and to determine normal limits in patients with normal myocardial perfusion using two (4D-MSPECT ve SIEMENS ICON® QGS)computer software programs.   Patients and Methods One hundred nine females were included study with the suspicion of CAD but their g-MPS was reported as normal between October 2004 and February 2007. Single day rest-stress g-MPS protocol was applied. Modified Bruce protocol was done for effort test with tredmill performance or dobutamine injection for pharmacological effort. Reconstruction was performed via Butterworth filtration without attenuation correction. LVEF, ESV and EDV were calculated.   Results The mean rest (REF) and stress (SEF) ejection fraction values between 4DM and QGS algorithms had significant differeneces statistically (∆REF[4DM-QGS])=9.5; ∆SEF[4DM-QGS]=8.9; p<0.05). Wide Blandt Alman limits (BAL) were detected among the results (BAL:[4DM-REF]-[QGS-REF]=26.4-(-7.8), R=0,61 P<0,05; 4DM-SEF-QGS-SEF:27.7-(-10.1), R=0,54; P=0,000). Significant differences (p<0.05) were found beside the strong correlation coefficient values (r=0.81-0.93) in the volumes.   Conclusion There were significant differences in the averages between the two g-MPS software program in LEVF and volume values so they should not be used in place of each other at the follow-up of patients. 

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