Abstract:

In this study, proton transfer salts (2apsba, 2Bzapsba, 2ampsba and 2a3OHpsba) between 2-methoxy-5-sulfamoylbenzoic acid (Hsba) and 2-aminopyridine (ap), 2-benzylaminopyridine (2Bzap), 2-aminomethylpyridine (2amp) and 2-amino-3-hydroxypyridine (2a3OHp) were synthesized. Starting materials and proton transfer salts of Enterococcus faecalis (ATCC 29212), Listeria monocytogenes (ATCC 7644), Bacillus subtilis, Staphylococcus aureus (NRRL-B 767) (Gram positive), Escherichia coli (ATCC 25922) and Pseudomonas aeruginosa (ATCC 27853) (Gram negative) bacteria and Candida Albicans (ATCC 14053) yeast of antibacterial and antifungal activities against were investigated. Antifungal activities were compared with Fluconazole and antibacterial activities with Cefepime, Vancomycin and Levofloxacin. The compounds used and synthesized in the experiment have activity against bacteria and yeasts. The best activity values of the compounds were observed 2Bzap and 2a3OHp (31.25 µg/mL) in B. subtilis bacteria, all compounds (except Hsba) (62.50 µg/mL) in E. faecalis and S. aureus bacteria, 2a3OHpsba (15.60 µg/mL) in E. coli bacteria, 2Bzapsba, Hsba, 2Bzap, 2amp and 2a3OHp (31.25 µg/mL) in L. monocytogenes bacteria, Hsba (31.25 µg/mL) in P. aeruginoa bacteria and 2Bzap (31.25 µg/mL) in C. albicans yeast.

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