Abstract:

The study aimed to exhibit liver protection, activity, and probable side effects of LPJE on a steatohepatitis rabbit model. In this study, 48 rabbits were used. The first group (Group 1) rabbits were fed a standard diet (SD), while the second group (Group 2) rabbits were fed a high-fat diet (HFD). In two groups, three different doses of LPJE (25 mg/kg, 50 mg/kg, and 100 mg/kg) were given simultaneously to the rabbits for eight weeks. Results showed that the serum albumin concentration was significantly different in the LPJE group (100 mg/kg) than in the positive control group. The cholesterol concentration of the LPJE (50mg/kg) administered subgroup of Group 2 (96.71 ± 12.03) was found to be the lowest. According to histopathological examination results, Group 2 did not display a statistical difference; however, the lowest liver fat deposition degree was 26.49 ± 8.64% in the LPJE (50 mg/kg) subgroup. As a result of this study, the lyophilized pomegranate extract has hepatoprotective activity. The most effective dose was 50 mg/kg on the non-alcoholic steatohepatitis (NASH) rabbit model. No side effects were determined up to 100 mg/kg pomegranate juice extract on rabbits.