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The aim of the study was to find methods for optimizing perioperative analgesia, stabilizing hemodynamics, improving control of in Materials and methods: The study included 53 patients, divided into 2 groups: primary (n=28) and control (n=25). In the main group, infusion of dexmedetomidine and intravenous form of paracetamol was carried out. The hemodynamic parameters, the general blood test, the coagulogram, the volume of blood loss, the duration of anesthesia and surgical intervention, the dose of anesthetics and analgesics, the pain level according to the VAS were investigated. Results: In the "P + D" group mean arterial pressure, heart rate and systolic index during induction of anesthesia, intubation, surgical intervention and after awakening of patients are significantly lower than in the control (p<0,001). The level of ANI at all stages of observation is significantly higher in the group "P + D" (p<0,001). The level of hemoglobin, hematocrit and erythrocytes in the postoperative period is lower in the "K" group than in the "P + D" group (p<0,001). In the "P + D" group, the blood loss is significantly less than in the control group (p<0,001). In the "P + D" group, the duration of surgery and anesthesia, the dose of anesthetics and narcotic analgesics is significantly lower than in the control (p<0,001). In the "P + D" group, Duke bleeding time and Lee-White coagulation time (p<0,001) is significantly shorter. Responses of patients are higher in the "P + D" group. The quality of visualization of the operating field is better in the group "P + D" (p<0,001). In the future, it is planned to conduct BIS studies to identify correlation with ANI and other indicators and compare ANI scores with such methods of objectifying the intraoperative level of pain as assessment of skin conductivity, determination of pupillary response, measurement of pulse wave amplitude and the like. However, this study is limited in renal, hepatic insufficiency and unstable hemodynamics. ANI is not interpreted in the following situations: atrial fibrillation, absence of breathing, respiratory rate less than 9 per 1 minute, presence of a pacemaker, use of atropine, adrenaline. The intravenous form of paracetamol and dexmedetomidine can be recommended for use in practical activities in nasal surgery to optimize anesthetic maintenance. Conclusion: Combination of dexmedetomidine and paracetamol with septoplasty allows to provide a reliable analgesia in the perioperative period. The introduction of dexmedetomidine and paracetamol correlates with the stabilization of hemodynamics in the perioperative period. Infusion of dexmedetomidine and paracetamol helps to reduce intraoperative blood loss and improve the visualization of the operating field Author Biographies Aleksandr Ayvardgi, Municipal Institution "Dnipropetrovsk City Clinical Hospital 8" of the Dnipropetrovsk Oblast Council Kosmichna str., 19, Dnipro, Ukraine, 49100 Doctor-аnaesthesiologist Department of Anaesthesiology and Intensive Care

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