Özet:

Erythema multiforme is an immune- mediated skin disorder characterized by erythematous target –like macules, papules and plaques commonly located over distal extremities as well as mucosal involvement. It is mostly induced by herpes simplex infections and various medications. Recurrences of herpes simplex infections result in new erythema multiforme lesions in immunologically susceptible people. Therefore, suppressing herpes reactivations also suppresses erythema multiforme attacks. Antiviral medications such as acyclovir, valacyclovir and famciclovir have limited capacity to prevent such recurrences due to their inadequate efficiency after continuous use . Those patients usually seek an absolute remedy to prevent recurrences. Bromelain is a well-known herbal supplement containing proteolytic enzymes produced from pineapple plant. It has been used in many clinical conditions including sinusitis, sports injuries and neoplastic diseases for years with a great safety profile. Herein, we present a young female patient with long -term erythema multiforme attacks induced by herpes simplex infections. She became free of disease after using oral bromelain 500 mg twice a day for one year.