Özet:

According to the DSM IV, a person who suffers from depressive disorder must either have a depressed mood or a loss of interest or pleasure in daily activities consistently for at least a two week period. In spite of our increasing knowledge about the pathophysiology of depression and the mechanisms of antidepressant treatments, there are some unmet clinical needs like the high rate of lack of response to antidepressants and the time lag before the action of conventional therapeutics. Many agents with effective antidepressant agents action amplify serotonin or norepinephrine signaling by inhibiting reuptake at the synaptic cleft, but they also have many side-effects due to binding to unrelated receptors. Calcium ion is dysregulated in depression. The dihydropyridine calcium channel antagonists in the mouse behavioral despair test was investigated. According to the results there has been affirm that dihydropyridine's may have antidepressant efficacy.

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