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Cytotoxic and apoptotic potential of some coumarin and 2-amino-3-carbonitrile selenophene derivatives in prostate cancer
2021
Journal:  
Turkish Journal of Chemistry
Author:  
DOI:  
10.3906/kim-2008-56
Abstract:

3-acetyl coumarin derivatives (1a-d) are formed as a result of condensation of salicylaldehyde derivatives and ethyl acetoacetate and were converted into coumarin-selenophene hybrid compounds (2a-d) in the basic medium by modified Gewald reaction in the presence of malononitrile and selenium. Products are characterized by nuclear magnetic resonance (NMR). The prepared compounds are screened for their anticancer activity against DU-145 cell line. In addition, selected target compounds are evaluated for apoptosis and oxidative stress on DU-145 (prostate carcinoma) cell lines.

Keywords:

null
2021
Journal:  
Turkish Journal of Chemistry
Author:  
DOI:  
10.3906/kim-2008-56
0
2021
Journal:  
Turkish Journal of Chemistry
Author:  
DOI:  
10.3906/kim-2008-56
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Information: There is no ciation to this publication.
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Turkish Journal of Chemistry

Field :   Fen Bilimleri ve Matematik

Journal Type :   Uluslararası

Metrics
Article : 2.410
Cite : 1.692
2023 Impact : 0.068
Details
Turkish Journal of Chemistry