Abstract:

Melatonin (N-acetyl-5-methoxytryptamine),the main secretory product of the pineal gland, is a free radical scavenger that has been found to protect against lipid peroxidation in many experimental models. In the present many study the effect of melatonin on lipid peroxidation of long chain polyunsaturated fatty acids located in rat. The most sensitive fatty acids in the heart were the monounsaturated eicosenoik acid (C20:1 n-6), polyunsaturated arachidonic acid (C20:4 n-6) docosapenthonoic acid (C22:5 n-3) and docosahexanoic acid (C22:6 n-3) which compared with the corresponding control values. I/R performed group showed remarkable differerences (p<0.05).In this study, myokardial-iscemia reperfusion is determined to cause increase or decreasa in different types of fatty acids.

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