Abstract:

Purpose: Carotic plaques are divided into calcium, mixed and fatty types according to the morphological substructure. As a result of the composition and instability of mixed and fatty carotenoid plates, increased ruptura, tromboembolism and stroke risk are more noticeable. This study aimed at evaluating the role of monocyte/high-intensity lipoprotein cholesterol (HDL-C) (MHR) and fat plaques in the forecast in patients with medium carotenous arterial density. Method: In this retrospective cohort study, a total of 223 asymptomatic patients with 50-70% stenosis in the carotic artery were taken. Patients were divided into three groups according to the plaque morphology: those with 94 calcium, 71 mixture and 58 fatty plaques. The groups were compared with MHR. The predictive role of MHR for mixed and fatty plates has been studied. Results: MHR was significantly higher in the mixed and fatty plaque group (16,951±5,935 vs 20,181±9,405 vs 11,200±4,126, p<0,001). The mixed plate was above the estimated 13.61 cut-off value, with 71.8 % sensitivity and 56.6 % specificity [the area below the point (EAA): 0.645, 95 % confidence range (GA): 0.571-0.718, p=0,001]. Furthermore, MHR was above the estimated 14.40 cut-off value for fat plate, 77.6 % sensitivity and 62.4 % specificity (EAA: 0.746, 95 % GA: 0.675-0.818, p<0,001). In the multi-variable regression analysis; after the adjustment of other risk factors, in the mid-level carotic artery density, MHR was a significant independent predictor of both mixed [probability ratio (OO): 1,230, p<0,001) and fatty (OO: 1,364, p<0,001) plates. The result: MHR plays a positive role in the prediction of mixed and fatty plaques in the asymptomatic medium carotenous arterial stenosis.

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