Abstract:

In clinical microbiology and antibacterial research, the significance of drug-resistant pathogens is growing up. Hydrazine-type compounds constitute the main classes of chemicals for the investigation of multidrug resistant agents which causes microbial infections. In the current study antimicrobial activities of certain Naphthalenylmethylen Hydrazine derivatives were examined to appraise their efficacy. The effectiveness of new compounds were evaluated using 2-fold serial dilutions against Staphylococcus aureus, Methicillin-Resistant-Staphylococcus aureus (MRSA), Enterococcus faecalis, Pseudomonas aeruginosa, Escherichia coli, and Candida albicans. Minimum inhibitory concentration (MIC) was determined for test compounds and for the reference standards Ciprofloxacin, ampicillin, and miconazole. According to the results, although the new compounds demonstrated poor antibacterial effects in general, the 1e and 1h compounds showed off significant antibacterial effects, especially against MRSA strains.

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