Özet:

Objective: The role of noninvasive serological markers is increasing in the diagnosis of inflammatory bowel diseases IBD . In this study, we aimed to evaluate the use of four different autoantibodies in the differential diagnosis in patients diagnosed with ulcerative colitis UC and Crohn's Disease CD .Material and Methods: 122 patients with IBD were included in the study. Seventy patients 57.3% were diagnosed with UC and 52 42.7% were diagnosed with CD. Demographic and clinical data were recorded; anti-neutrophil cytoplasmic antibody ANCA , anti-intestinal goblet antibody AIGA , anti Saccharomyces cerevisiae antibody, ASCA and anti-exocrine pancreatic antibody AEPA were studied using immunofluorescence. Data were analyzed with the SPSS 17.0 program.Results: ANCA, ASCA and AEPA antibodies had high specificities 96.1%, 94.2% and 98.5%, respectively . The highest test accuracy was seen in ASCA with 73.7%, and the lowest test accuracy was seen in ANCA with 55.7%. In addition, ANCA-positive UC patients had experienced more attacks than ANCA-negative patients ANCA-positive 7.61±3.3 attacks, ANCA-negative 4.98 ± 3.3 attacks ; similarly, ASCA positive CD patients also had more attacks than ASCA negatives ASCA positive 5.04±3.5 attacks, ASCA negative 3.3±1.9 attacks .Conclusion: ANCA, ASCA and AEPA have high specificity and positive predictive values in the differential diagnosis of UC and CD. However, their clinical use is limited due to the low positivity rates of antibodies in patient populations. The positivity of ANCA and ASCA antibodies has also been associated with the number of UC and CH attacks, and may have prognostic significance for the course of severe disease

Anahtar Kelimeler: