Görüntüleme
12
İndirme
3
Biyoaktif flavonoidler, insan için birçok biyolojik faydalar sağlayan gıdadaki en önemli fitokimyasallar olarak kabul edilir. Antioksidan, anti-bakteriyel, anti-kolinerjik, anti-diyabetik, anti-mutajenik ve anti-enflamatuar özellikler gibi birçok farmakolojik aktiviteye sahiptirler. Flavonoidlerin bir üyesi olan morin, nükleik asitler, enzimler ve proteinler ile etkileĢime girerek birçok terapötik özellik sergiler. Bu çalıĢmada, doğal fenolik bir bileĢik olarak morin, insan karbonik anhidraz (CA) izoformları I ve II (CA I ve II), asetilkolinesteraz (AChE) ve 𝛼-glikozidaz enzimlerine karĢı inhibe edici etkiler göstermiĢtir. Bu fenolik bileĢik, CA I, CA II, AChE ve 𝛼-glikozidaz enzimlerinin inhibisyonu için test edildi ve sırasıyla CA I için 31.89 ± 9.07 nM, CA II için 49.25 ± 12.85 nM, AChE için 184.67 ± 30.37 nM ve 𝛼-glikozidaz için 16.99 ± 4.40 nM Ki değerleri ile etkili inhibisyon profilleri gösterdi.
Bioactive flavonoids are considered to be the most important phytochemicals in food that provide many biological benefits for humans. They have many pharmacological activities such as antioxidant, anti-bacterial, anti-colinergic, anti-diabetic, anti-mutagenic and anti-inflammatory properties. Morin, a member of the flavonoids, interacts with nuclear acids, enzymes and proteins, showing many therapeutic properties by entering it. As a natural phenolic substance, the human carbonic anhidrazis (CA) isophores I and II (CA I and II), acetylcholinesterase (AChE) and α-glycosidase enzymes have an inhibiting effect. This phenolic compound was tested for the inhibition of CA I, CA II, AChE and α-glycosidase enzymes and respectively 31.89 ± 9.07 nM for CA I, and 49.25 ± 12 for CA II. 85 nM showed effective inhibition profiles with the values of 184.67 ± 30.37 nM for AChE and 16.99 ± 4.40 nM Ki for α-glycosidase.
Bioactive flavonoids are considered to be the most important phytochemicals in food that provide many biological benefits for human beings. They have many pharmacological activities that include antioxidant, anti-bacterial, anti-cholinergic, anti-diabetic, anti-mutagenic and anti-inflammatory properties. Morin, a member of flavonoids, exhibit many therapeutic properties by interacting with nucleic acids, enzymes and protein. In this study, morin as natural a phenolic compound showed inhibitory effects against human carbonic anhydrase (CA) isoforms I and II (CA I and II), acetylcholinesterase (AChE) and 𝛼-glycosidase enzymes. This phenolic compound was tested for the inhibition of CA I, CA II, AChE, and 𝛼-glycosidase enzymes and demonstrated efficient inhibition profiles with Ki value of 31.89 ± 9.07 nM for CA I, 49.25 ± 12.85 nM for CA II, 184.67 ± 30.37 nM for AChE, and 16.99 ± 4.40 nM for 𝛼-glycosidase, respectively.
Dergi Türü : Uluslararası
Makale Detay 
Benzer Makaleler
PDF Görüntüle
Dergi Bilgisi
Eseri Dinleyin
Alıntı Yap
Bu Sayfayı Yazdırın
Paylaş
Mendeley
