Abstract:

This study was carried out to determine the protective effects of dexpantenol and boldin against the possible testicular damage caused by sisplatine. In the study, 48 pieces of 4-5 months old male Wistar rat (250-270 g) were used. There were eight groups of animals in each group. Rats were given boldin (20 and 40 mg/kg) and dexpantenol (250 and 500 mg/kg) together with sisplatin (7 mg/kg). At the end of the 14th day, spermatological and histopatological examinations measured the levels of testicular tissue malondaldehyde (MDA), superoxid dismutase (SOD), glutation peroxidase (GSH-Px) and catalase (CAT). A significant decrease in sperm quality and motility in the Sisplatin group, a significant increase in MDA, a significant decrease in SOD, GSH-Px, CAT levels. The levels of MDA in other groups have decreased significantly compared to the group of sisplatin. In the treatment groups, the levels of SOD, GSH-Px and CAT enzymes increased according to the group of siplatin and approached the level of the control group. The combined application of high doses of both substances with sisplatin reduced histopathological lesions. In the groups where both doses of Decspantenol and Bollatin were administered in combination with Sisplatin, significant increases were observed according to the group of Sisplatin. As a result, it was found that the use of dexpantenol and boldin against the testicular damage caused by sisplatin in rats could have a protective effect.

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