Özet:

Objective: In this study, it was aimed to determine the resistance rates of E. coli strains that cause urinary infections in our region against commonly used antibiotics in the clinic and to guide these findings in empirical antibiotic therapy. Material and Methods: In the study, antibiotic susceptibility of E. coli strains isolated from urine cultures obtained from outpatients between June 2022 and June 2023 in the Infectious Diseases and Clinical Microbiology Laboratory of Kırıkkale University Medical Faculty Hospital was studied with BD Phoenix™ M50 automated system. Results: A total of 434 E. coli strains isolated from 335 female and 99 male patients were included in the study. It was determined that 43 (9.9%) of 434 strains produced extended spectrum beta-lactamases. The highest resistance rates against E. coli strains were determined against fluoroquinolones and third-generation cephalosporins, while the lowest resistance rates were determined against carbapenems, amikacin, fosfomycin and nitrofurantoin. Conclusion: Considering the resistance rates obtained in the study, fosfomycin, nitrofurantoin and TMP-SXT are seen as suitable treatment options in our region for the empirical outpatient treatment of patients with simple cystitis. Empirical use of fluoroquinolones should be avoided due to high rates of resistance. Carbapenems and amikacin are also seen as suitable treatment options in the treatment of extended spectrum beta- lactamases producing strains.