Views
16
Downloands
2
İn this study, ameliorating effects of N-Acetylcysteine, a potent free radical scavenger, on paraquat-induced oxidative stress were investigated. N-Acetylcysteine (NAC, 50 mg/kg, i.p.) was administered one hour prior to the administration of paraquat (PQ, 40 mg/kg, i.p.). Malondialdehyde (MDA) and gluthathione (GSH) levels were determined as markers of oxidative stress. After PQ treatment, significant changes were observed in both MDA and GSH levels (p<0.001). Pretreatment with NAC, prevented PQ-induced increases in plasma (p<0.01); liver, kidney, lung (p<0.001) and brain (p<0.05) MDA levels. NAC when administered prior to PQ injection, caused significant amelioration in liver, lung, brain (p<0.01) and kidney (p<0.05) GSH levels
Field : Sağlık Bilimleri
Journal Type : Uluslararası
Article Detail 
Similar Articles
Journal Information
Listen Paper
Cite
Print This Page
Share
Mendeley
