Görüntüleme
22
İndirme
3
Amaç: Bu çalışmanın amacı böbrek hücreli karsinomlarda (BHK) yeni prognostik belirteçlerin belirlenmesine yardımcı olmak, otofajinin BHK patogenezindeki rolünü göstermek ve BHK'daki yeni tedavi yöntemlerine ışık tutmaktır. Gereç ve Yöntemler: Klinikopatolojik evreler, tümör nekrozu ve mikrovasküler invazyon (MVI) retrospektif olarak belirlendi ve Beclin-1, Ki-67 ve p53 immünohistokimyasal olarak incelendi. Bulgular: BHK’larında tümör nekrozu, MVI, Ki-67 ve p53 Fuhrman nükleer derece ve patolojik tümör evresi ile pozitif korelasyon gösterirken, Beclin-1 sadece nükleer derece ile ilişkiliydi. MVI ve Ki-67, uzak organ ve lenf nodu metastazı ile ilişkiliydi. Ki-67 ve nekroz, p53 ve Beclin-1 ekspresyonu ile pozitif koreleydi ancak MVI ile korele değildi. Beclin-1 nekroz ile koreleydi, ancak p53 ve MVI ile korele değildi. p53, Ki-67 ve MVI sağkalım ile negatif korelasyon gösterirken Beclin -1 ve nekrozun sağkalım üzerindeki etkisi gösterilemedi. Sonuç: BHK’larda Ki-67, p53 ve MVI sağkalım üzerine etkileri olan prognostik parametrelerdir. Beclin-1, sağkalım ile ilişkili bir prognostik parametre olmamasına rağmen, tümör dokusunda ekspresyonunun arttığı bulundu. Aynı zamanda, tümör dışı böbrek parankiminde daha az boyama vardır. Beclin-1, otofajinin bir belirtecidir ve prognostik öneminden ziyade BHK patogenezinde rol oynadığı düşünülmektedir.
Purpose: The aim of this study is to help identify new prognostic indicators in kidney cell carcinomas (BHK), to show the role of autofay in BHK pathogenesis and to keep light on the new methods of treatment in BHK. Clinic pathological stages, tumor necrosis and microvascular invasion (MVI) were determined retrospectively and Beclin-1, Ki-67 and p53 were immunohistochemically studied. The findings: The tumor necrosis in the BHK, MVI, Ki-67 and p53 showed a positive correlation with the Fuhrman nuclear degree and pathological tumor stage, while Beclin-1 was only related to the nuclear degree. MVI and Ki-67 were associated with the metastasis of the remote organ and lymph nodes. Ki-67 and necrosis were positive corele with the expression of p53 and Beclin-1, but they were not corele with MVI. Beclin-1 was correlated with necrosis, but it was not correlated with p53 and MVI. P53, Ki-67 and MVI had a negative correlation with survival, but the effect of Beclin-1 and necrosis on survival was not shown. Results: BHKs are prognostic parameters that have an impact on Ki-67, p53 and MVI survival. Beclin-1, although there is no prognostic parameter associated with survival, it was found that its expression in the tumor tissue increased. At the same time, there is less coloring in the non-tumor renal parankym. Beclin-1 is a sign of autophysics and it is believed to play a role in BHK pathogenesis rather than prognostic importance.
Aim: The aim of this study was to help identify new prognostic markers in renal cell carcinomas (RCC), to show the role of autophagy in the pathogenesis of RCC and to shed light on new treatment modalities in RCC. Material and Methods: Clinicopathological stages, tumor necrosis and microvascular invasion (MVI) were determined retrospectively and Beclin-1, Ki-67, and p53 were studied immunohistochemically. Results: Tumor necrosis, MVI, Ki-67, and p53 in RCCs were positively correlated with Fuhrman nuclear grade and pathologic tumor stage, while Beclin-1 was only associated with nuclear grade. MVI and Ki-67 were associated with distant organ and lymph node metastasis. Ki-67 and necrosis correlated positively with p53 and Beclin-1 expression, but not with MVI. Beclin-1 were positively correlated necrosis, but not with p53 and MVI. p53, Ki-67 and MVI were negatively correlated with survival, while the effect of Beclin -1 and necrosis on survival couldn’t be demonstrated. Conclusion: Ki-67, p53, and MVI in RCCs are prognostic parameters with effects on survival. Although Beclin-1 was not a prognostic parameter associated with survival, its expression in tumor tissue was found to be increased. At the same time, there is less staining in non-tumor renal parenchyma. Beclin-1 is a marker of autophagy and is thought to be involved in RCC pathogenesis rather than its prognostic significance.
Alan : Sağlık Bilimleri
Dergi Türü : Uluslararası
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